Have

Persistent Constrictor

At the beginning of each opponent's upkeep, they lose 1 life and you put a -1/-1 counter on up to one target creature they control.
Persist (When this creature dies, if it had no -1/-1 counters on it, return it to the battlefield under its owner's control with a -1/-1 counter on it.)

Vincent

Night Market Lookout

Whenever Night Market Lookout becomes tapped, each opponent loses 1 life and you gain 1 life.

Sol Ring

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Rakdos Carnarium

Rakdos Carnarium enters tapped.
When Rakdos Carnarium enters, return a land you control to its owner's hand.
{T}: Add {B}{R}.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Immolation Shaman

Whenever an opponent activates an ability of an artifact, creature, or land that isn't a mana ability, Immolation Shaman deals 1 damage to that player.
{3}{R}{R}: Immolation Shaman gets +3/+3 and gains menace until end of turn.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Cursed Mirror

{T}: Add {R}.
As Cursed Mirror enters, you may have it become a copy of any creature on the battlefield until end of turn, except it has haste.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Graven Cairns

{T}: Add {C}.
{B/R}, {T}: Add {B}{B}, {B}{R}, or {R}{R}.

Haunted Ridge

Haunted Ridge enters tapped unless you control two or more other lands.
{T}: Add {B} or {R}.

Sulfurous Springs

{T}: Add {C}.
{T}: Add {B} or {R}. Sulfurous Springs deals 1 damage to you.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Abrade

Choose one —
• Abrade deals 3 damage to target creature.
• Destroy target artifact.

Don't Have

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Blazemire Verge

{T}: Add {B}.
{T}: Add {R}. Activate only if you control a Swamp or a Mountain.

Termination Facilitator

{T}: Put a bounty counter on target creature or planeswalker. Activate only as a sorcery.
Whenever a creature or planeswalker an opponent controls with a bounty counter on it is dealt damage, destroy it.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Razorkin Needlehead

Razorkin Needlehead has first strike during your turn.
Whenever an opponent draws a card, Razorkin Needlehead deals 1 damage to them.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Return the Favor

Spree (Choose one or more additional costs.)
+ {1} — Copy target instant spell, sorcery spell, activated ability, or triggered ability. You may choose new targets for the copy.
+ {1} — Change the target of target spell or ability with a single target.

Barbed Wire

At the beginning of each player's upkeep, Barbed Wire deals 1 damage to that player.
{2}: Prevent the next 1 damage that would be dealt by Barbed Wire this turn.

Rampaging Ferocidon

Menace
Players can't gain life.
Whenever another creature enters, Rampaging Ferocidon deals 1 damage to that creature's controller.

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Twinflame Tyrant

Flying
If a source you control would deal damage to an opponent or a permanent an opponent controls, it deals double that damage instead.

Disciple of the Vault

Whenever an artifact is put into a graveyard from the battlefield, you may have target opponent lose 1 life.

Luxury Suite

Luxury Suite enters tapped unless you have two or more opponents.
{T}: Add {B} or {R}.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Blood Pact

Target player draws two cards and loses 2 life.

Tainted Peak

{T}: Add {C}.
{T}: Add {B} or {R}. Activate only if you control a Swamp.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Smoldering Marsh

({T}: Add {B} or {R}.)
Smoldering Marsh enters tapped unless you control two or more basic lands.

Roiling Vortex

At the beginning of each player's upkeep, Roiling Vortex deals 1 damage to them.
Whenever a player casts a spell, if no mana was spent to cast that spell, Roiling Vortex deals 5 damage to that player.
{R}: Your opponents can't gain life this turn.

Virtus the Veiled

Partner with Gorm the Great (When this creature enters, target player may put Gorm into their hand from their library, then shuffle.)
Deathtouch
Whenever Virtus the Veiled deals combat damage to a player, that player loses half their life, rounded up.

Unstoppable Slasher

Deathtouch
Whenever Unstoppable Slasher deals combat damage to a player, they lose half their life, rounded up.
When Unstoppable Slasher dies, if it had no counters on it, return it to the battlefield tapped under its owner's control with two stun counters on it.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Ankh of Mishra

Whenever a land enters, Ankh of Mishra deals 2 damage to that land's controller.

Dragonskull Summit

Dragonskull Summit enters tapped unless you control a Swamp or a Mountain.
{T}: Add {B} or {R}.

Oppression

Whenever a player casts a spell, that player discards a card.

Mountain

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Sadistic Shell Game

Starting with the next opponent in turn order, each player chooses a creature you don't control. Destroy the chosen creatures.

Rev, Tithe Extractor

Whenever you attack, target creature gains deathtouch until end of turn.
Whenever one or more creatures you control deal combat damage to a player, create a Treasure token, then look at the top card of that player's library and exile it face down. You may cast that card for as long as it remains exiled. (A Treasure token is an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Valgavoth, Harrower of Souls

Flying
Ward—Pay 2 life.
Whenever an opponent loses life for the first time during each of their turns, put a +1/+1 counter on Valgavoth, Harrower of Souls and draw a card.

Suspended Sentence

Destroy target creature an opponent controls. That player loses 3 life. Exile Suspended Sentence with three time counters on it.
Suspend 3—{1}{B} (Rather than cast this card from your hand, you may pay {1}{B} and exile it with three time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)

Kederekt Parasite

Whenever an opponent draws a card, if you control a red permanent, you may have Kederekt Parasite deal 1 damage to that player.

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature of their choice.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Swamp

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Grab the Prize

As an additional cost to cast this spell, discard a card.
Draw two cards. If the discarded card wasn't a land card, Grab the Prize deals 2 damage to each opponent.

Sunscorched Desert

When Sunscorched Desert enters, it deals 1 damage to target player or planeswalker.
{T}: Add {C}.

Arcane Signet

Nightshade Harvester

Whenever a land an opponent controls enters, that player loses 1 life. Put a +1/+1 counter on Nightshade Harvester.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Bloodfell Caves

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {B} or {R}.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Searstep Pathway

Blightstep Pathway

Blightstep Pathway // Searstep Pathway

Shivan Gorge

{T}: Add {C}.
{2}{R}, {T}: Shivan Gorge deals 1 damage to each opponent.

Blood Crypt

({T}: Add {B} or {R}.)
As Blood Crypt enters, you may pay 2 life. If you don't, it enters tapped.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Sign in Blood

Cemetery Gatekeeper

First strike
When Cemetery Gatekeeper enters, exile a card from a graveyard.
Whenever a player plays a land or casts a spell, if it shares a card type with the exiled card, Cemetery Gatekeeper deals 2 damage to that player.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Jagged Barrens

Jagged Barrens enters tapped.
When Jagged Barrens enters, it deals 1 damage to target opponent.
{T}: Add {B} or {R}.

Saw in Half

Destroy target creature. If that creature dies this way, its controller creates two tokens that are copies of that creature, except their power is half that creature's power and their toughness is half that creature's toughness. Round up each time.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy Lethal Vapors. You skip your next turn. Any player may activate this ability.

Untimely Malfunction

Choose one —
• Destroy target artifact.
• Change the target of target spell or ability with a single target.
• One or two target creatures can't block this turn.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Enchanter's Bane

At the beginning of your end step, target enchantment deals damage equal to its mana value to its controller unless that player sacrifices it.

Rottenmouth Viper

As an additional cost to cast this spell, you may sacrifice any number of nonland permanents. This spell costs {1} less to cast for each permanent sacrificed this way.
Whenever Rottenmouth Viper enters or attacks, put a blight counter on it. Then for each blight counter on it, each opponent loses 4 life unless that player sacrifices a nonland permanent of their choice or discards a card.