Brink of Madness

At the beginning of your upkeep, if you have no cards in hand, sacrifice Brink of Madness and target opponent discards their hand.

Hopeless Nightmare

When Hopeless Nightmare enters, each opponent discards a card and loses 2 life.
When Hopeless Nightmare is put into a graveyard from the battlefield, scry 2.
{2}{B}: Sacrifice Hopeless Nightmare.

Bloodtithe Collector

Flying
When this creature enters, if an opponent lost life this turn, each opponent discards a card.

Liliana's Spoils

Target opponent discards a card.
Look at the top five cards of your library. You may reveal a black card from among them and put it into your hand. Put the rest on the bottom of your library in a random order.

Braids's Frightful Return

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — You may sacrifice a creature. If you do, each opponent discards a card.
II — Return target creature card from your graveyard to your hand.
III — Target opponent may sacrifice a nonland, nontoken permanent of their choice. If they don't, they lose 2 life and you draw a card.

Mind Drain

Target opponent discards two cards, mills a card, and loses 1 life. You gain 1 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Awaken the Erstwhile

Each player discards all the cards in their hand, then creates that many 2/2 black Zombie creature tokens.

Fell Specter

Flying
When Fell Specter enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Augur of Skulls

{1}{B}: Regenerate Augur of Skulls.
Sacrifice Augur of Skulls: Target player discards two cards. Activate only during your upkeep.

Whispers of Emrakul

Target opponent discards a card at random.
Delirium — If there are four or more card types among cards in your graveyard, that player discards two cards at random instead.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Tinybones, Bauble Burglar

Whenever an opponent discards a card, exile it from their graveyard with a stash counter on it.
During your turn, you may play cards you don't own with stash counters on them from exile, and mana of any type can be spent to cast those spells.
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Unnerve

Banshee of the Dread Choir

Myriad (Whenever this creature attacks, for each opponent other than defending player, you may create a token copy that's tapped and attacking that player or a planeswalker they control. Exile the tokens at end of combat.)
Whenever Banshee of the Dread Choir deals combat damage to a player, that player discards a card.

Deception

Caligo Skin-Witch

Kicker {3}{B} (You may pay an additional {3}{B} as you cast this spell.)
When Caligo Skin-Witch enters, if it was kicked, each opponent discards two cards.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Deadbridge Shaman

When Deadbridge Shaman dies, target opponent discards a card.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Cackling Fiend

When Cackling Fiend enters, each opponent discards a card.

Triumph of Cruelty

At the beginning of your upkeep, target opponent discards a card if you control the creature with the greatest power or tied for the greatest power.

Swamp

Bloodhusk Ritualist

Multikicker {B} (You may pay an additional {B} any number of times as you cast this spell.)
When Bloodhusk Ritualist enters, target opponent discards a card for each time it was kicked.

Ashiok's Adept

Heroic — Whenever you cast a spell that targets Ashiok's Adept, each opponent discards a card.

The One Ring

Indestructible
When The One Ring enters, if you cast it, you gain protection from everything until your next turn.
At the beginning of your upkeep, you lose 1 life for each burden counter on The One Ring.
{T}: Put a burden counter on The One Ring, then draw a card for each burden counter on The One Ring.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Corrupt Court Official

When Corrupt Court Official enters, target opponent discards a card.

Tinybones, the Pickpocket

Deathtouch
Whenever Tinybones, the Pickpocket deals combat damage to a player, you may cast target nonland permanent card from that player's graveyard, and mana of any type can be spent to cast that spell.

The Raven Man

At the beginning of each end step, if a player discarded a card this turn, create a 1/1 black Bird creature token with flying and "This creature can't block."
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Tainted Aether

Whenever a creature enters, its controller sacrifices a creature or land of their choice.

Heartless Pillage

Target opponent discards two cards.
Raid — If you attacked this turn, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Maha, Its Feathers Night

Flying, trample
Ward—Discard a card.
Creatures your opponents control have base toughness 1.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Blood for Bones

As an additional cost to cast this spell, sacrifice a creature.
Return a creature card from your graveyard to the battlefield, then return another creature card from your graveyard to your hand.

Rush of Dread

Spree (Choose one or more additional costs.)
+ {1} — Target opponent sacrifices half the creatures they control of their choice, rounded up.
+ {2} — Target opponent discards half the cards in their hand, rounded up.
+ {2} — Target opponent loses half their life, rounded up.

Thoughtrender Lamia

Constellation — Whenever Thoughtrender Lamia or another enchantment you control enters, each opponent discards a card.

Oppression

Whenever a player casts a spell, that player discards a card.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Aspect of Lamprey

Enchant creature you control
When Aspect of Lamprey enters, target opponent discards two cards.
Enchanted creature has lifelink.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control of their choice, then sacrifices a third of the lands they control of their choice. Round up each time.

Cruel Grimnarch

Deathtouch
When Cruel Grimnarch enters, each opponent discards a card. For each opponent who can't, you gain 4 life.

Assassin's Strike

Destroy target creature. Its controller discards a card.

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Tinybones Joins Up

When Tinybones Joins Up enters, any number of target players each discard a card.
Whenever a legendary creature you control enters, any number of target players each mill a card and lose 1 life.

Bite of the Black Rose

Will of the council — Starting with you, each player votes for sickness or psychosis. If sickness gets more votes, creatures your opponents control get -2/-2 until end of turn. If psychosis gets more votes or the vote is tied, each opponent discards two cards.

Virus Beetle

When Virus Beetle enters, each opponent discards a card.

Sol Ring

The Eldest Reborn

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Each opponent sacrifices a creature or planeswalker of their choice.
II — Each opponent discards a card.
III — Put target creature or planeswalker card from a graveyard onto the battlefield under your control.

Demogorgon's Clutches

Target opponent discards two cards, mills two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Possessed Portal

If a player would draw a card, that player skips that draw instead.
At the beginning of each end step, each player sacrifices a permanent of their choice unless they discard a card.

Bandit's Talent

(Gain the next level as a sorcery to add its ability.)
When Bandit's Talent enters, each opponent discards two cards unless they discard a nonland card.
{B}: Level 2
At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 2 life.
{3}{B}: Level 3
At the beginning of your draw step, draw an additional card for each opponent who has one or fewer cards in hand.

God-Pharaoh's Statue

Spells your opponents cast cost {2} more to cast.
At the beginning of your end step, each opponent loses 1 life.

Myojin of Night's Reach

Myojin of Night's Reach enters with a divinity counter on it if you cast it from your hand.
Myojin of Night's Reach has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Night's Reach: Each opponent discards their hand.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy Lethal Vapors. You skip your next turn. Any player may activate this ability.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Cerebral Confiscation

Choose one —
• Target opponent discards two cards.
• Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.

Doomsday Confluence

Choose X. You may choose the same mode more than once.
• Each player sacrifices a nonartifact creature of their choice.
• Create a 3/3 black Dalek artifact creature token with menace.
• Each opponent discards a card.

Nyx Lotus

Nyx Lotus enters tapped.
{T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Blackmail

Target player reveals three cards from their hand and you choose one of them. That player discards that card.

Behold the Beyond

Discard your hand. Search your library for three cards, put them into your hand, then shuffle.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Junji, the Midnight Sky

Flying, menace
When Junji, the Midnight Sky dies, choose one —
• Each opponent discards two cards and loses 2 life.
• Put target non-Dragon creature card from a graveyard onto the battlefield under your control. You lose 2 life.

Let's Play a Game

Delirium — Choose one. If there are four or more card types among cards in your graveyard, choose one or more instead.
• Creatures your opponents control get -1/-1 until end of turn.
• Each opponent discards two cards.
• Each opponent loses 3 life and you gain 3 life.

Liliana's Specter

Flying
When Liliana's Specter enters, each opponent discards a card.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Harvest Fear

Target opponent discards two cards. (Then exile this card. You may cast the creature later from exile.)

Reaper of Night

Whenever Reaper of Night attacks, if defending player has two or fewer cards in hand, it gains flying until end of turn.

Reaper of Night // Harvest Fear

Abyssal Specter

Flying
Whenever Abyssal Specter deals damage to a player, that player discards a card.