Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Minion of the Wastes

Trample
As Minion of the Wastes enters the battlefield, pay any amount of life.
Minion of the Wastes's power and toughness are each equal to the life paid as it entered the battlefield.

Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Lithoform Blight

Enchant land
When Lithoform Blight enters the battlefield, draw a card.
Enchanted land loses all land types and abilities and has "{T}: Add {C}" and "{T}, Pay 1 life: Add one mana of any color."

Sidar Kondo of Jamuraa

Flanking (Whenever a creature without flanking blocks this creature, the blocking creature gets -1/-1 until end of turn.)
Creatures your opponents control without flying or reach can't block creatures with power 2 or less.
Partner (You can have two commanders if both have partner.)

Thrull Parasite

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
{T}, Pay 2 life: Remove a counter from target nonland permanent.

Adanto Vanguard

As long as Adanto Vanguard is attacking, it gets +2/+0.
Pay 4 life: Adanto Vanguard gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Angel of Grace

Flash
Flying
When Angel of Grace enters the battlefield, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile Angel of Grace from your graveyard: Your life total becomes 10.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice Gonti's Machinations: Each opponent loses 3 life. You gain life equal to the life lost this way.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Pontiff of Blight

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Other creatures you control have extort. (If a creature has multiple instances of extort, each triggers separately.)

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Moonlight Bargain

Look at the top five cards of your library. For each card, put that card into your graveyard unless you pay 2 life. Then put the rest into your hand.

Final Payment

As an additional cost to cast this spell, pay 5 life or sacrifice a creature or enchantment.
Destroy target creature.

Garza's Assassin

Sacrifice Garza's Assassin: Destroy target nonblack creature.
Recover—Pay half your life, rounded up. (When another creature is put into your graveyard from the battlefield, you may pay half your life, rounded up. If you do, return this card from your graveyard to your hand. Otherwise, exile this card.)

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Cruel Sadist

{B}, {T}, Pay 1 life: Put a +1/+1 counter on Cruel Sadist.
{2}{B}, {T}, Remove X +1/+1 counters from Cruel Sadist: It deals X damage to target creature.

Vesper Ghoul

{T}, Pay 1 life: Add one mana of any color.

Tree of Redemption

Defender
{T}: Exchange your life total with Tree of Redemption's toughness.

Phyrexian Colossus

Phyrexian Colossus doesn't untap during your untap step.
Pay 8 life: Untap Phyrexian Colossus.
Phyrexian Colossus can't be blocked except by three or more creatures.

Sengir, the Dark Baron

Flying
Whenever another creature dies, put two +1/+1 counters on Sengir, the Dark Baron.
Whenever another player loses the game, you gain life equal to that player's life total as the turn began.
Partner (You can have two commanders if both have partner.)

Multiform Wonder

When Multiform Wonder enters the battlefield, you get {E}{E}{E} (three energy counters).
Pay {E}: Multiform Wonder gains your choice of flying, vigilance, or lifelink until end of turn.
Pay {E}: Multiform Wonder gets +2/-2 or -2/+2 until end of turn.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Lich's Tomb

You don't lose the game for having 0 or less life.
Whenever you lose life, sacrifice a permanent for each 1 life you lost. (Damage causes loss of life.)

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Blightsoil Druid

Street Wraith

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
Cycling—Pay 2 life. (Pay 2 life, Discard this card: Draw a card.)

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Phyrexian Lens

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Dawn

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Return all creature cards with power 2 or less from your graveyard to your hand.