Progenitus

Protection from everything
If Progenitus would be put into a graveyard from anywhere, reveal Progenitus and shuffle it into its owner's library instead.

Apex Devastator

Cascade, cascade, cascade, cascade (When you cast this spell, exile cards from the top of your library until you exile a nonland card that costs less. You may cast it without paying its mana cost. Put the exiled cards on the bottom in a random order. Multiple instances of cascade each trigger separately.)

Lux Artillery

Whenever you cast an artifact creature spell, it gains sunburst. (It enters with a +1/+1 counter on it for each color of mana spent to cast it.)
At the beginning of your end step, if there are thirty or more counters among artifacts and creatures you control, Lux Artillery deals 10 damage to each opponent.

Ramos, Dragon Engine

Flying
Whenever you cast a spell, put a +1/+1 counter on Ramos for each of that spell's colors.
Remove five +1/+1 counters from Ramos: Add {W}{W}{U}{U}{B}{B}{R}{R}{G}{G}. Activate only once each turn.

Door to Nothingness

Door to Nothingness enters tapped.
{W}{W}{U}{U}{B}{B}{R}{R}{G}{G}, {T}, Sacrifice Door to Nothingness: Target player loses the game.