Perplexing Chimera

Whenever an opponent casts a spell, you may exchange control of Perplexing Chimera and that spell. If you do, you may choose new targets for the spell. (If the spell becomes a permanent, you control that permanent.)

Thought Prison

Imprint — When Thought Prison enters, you may have target player reveal their hand. If you do, choose a nonland card from it and exile that card.
Whenever a player casts a spell that shares a color or mana value with the exiled card, Thought Prison deals 2 damage to that player.

Breena, the Demagogue

Flying
Whenever a player attacks one of your opponents, if that opponent has more life than another of your opponents, that attacking player draws a card and you put two +1/+1 counters on a creature you control.

Overburden

Whenever a player puts a nontoken creature onto the battlefield, that player returns a land they control to its owner's hand.

Managorger Hydra

Trample
Whenever a player casts a spell, put a +1/+1 counter on Managorger Hydra.

Possibility Storm

Whenever a player casts a spell from their hand, that player exiles it, then exiles cards from the top of their library until they exile a card that shares a card type with it. That player may cast that card without paying its mana cost. Then they put all cards exiled with Possibility Storm on the bottom of their library in a random order.

Scrawling Crawler

At the beginning of your upkeep, each player draws a card.
Whenever an opponent draws a card, that player loses 1 life.

Gleeful Arsonist

Whenever an opponent casts a noncreature spell, Gleeful Arsonist deals damage equal to its power to that player.
Undying (When this creature dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Immolation Shaman

Whenever an opponent activates an ability of an artifact, creature, or land that isn't a mana ability, Immolation Shaman deals 1 damage to that player.
{3}{R}{R}: Immolation Shaman gets +3/+3 and gains menace until end of turn.

Nekusar, the Mindrazer

At the beginning of each player's draw step, that player draws an additional card.
Whenever an opponent draws a card, Nekusar, the Mindrazer deals 1 damage to that player.

Ruric Thar, the Unbowed

Vigilance, reach
Ruric Thar, the Unbowed attacks each combat if able.
Whenever a player casts a noncreature spell, Ruric Thar deals 6 damage to that player.

Counterbalance

Whenever an opponent casts a spell, you may reveal the top card of your library. If you do, counter that spell if it has the same mana value as the revealed card.

Glowing One

Deathtouch
Whenever Glowing One deals combat damage to a player, they get four rad counters.
Whenever a player mills a nonland card, you gain 1 life.

Malik, Grim Manipulator

When Malik, Grim Manipulator enters, you and target opponent each secretly choose a creature that player controls. Then those choices are revealed, and that player sacrifices those creatures.
Whenever an opponent sacrifices a creature, you create a Treasure token.

Phyrexian Tyranny

Whenever a player draws a card, that player loses 2 life unless they pay {2}.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Steam Clean

Return target nonland permanent to its owner's hand. (Then exile this card. You may cast the creature later from exile.)

Scalding Viper

Whenever an opponent casts a spell with mana value 3 or less, Scalding Viper deals 1 damage to that player.

Scalding Viper // Steam Clean

It That Betrays

Annihilator 2 (Whenever this creature attacks, defending player sacrifices two permanents of their choice.)
Whenever an opponent sacrifices a nontoken permanent, put that card onto the battlefield under your control.

Nazgûl Battle-Mace

Equipped creature has menace, deathtouch, annihilator 1, and "Whenever an opponent sacrifices a nontoken permanent, put that card onto the battlefield under your control unless that player pays 3 life." (Whenever a creature with annihilator 1 attacks, defending player sacrifices a permanent of their choice.)
Equip {3}

Mangara, the Diplomat

Lifelink
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, draw a card.
Whenever an opponent casts their second spell each turn, draw a card.

Soot Imp

Flying
Whenever a player casts a nonblack spell, that player loses 1 life.

Eidolon of the Great Revel

Whenever a player casts a spell with mana value 3 or less, Eidolon of the Great Revel deals 2 damage to that player.

Lurking Predators

Whenever an opponent casts a spell, reveal the top card of your library. If it's a creature card, put it onto the battlefield. Otherwise, you may put that card on the bottom of your library.

Spiteful Visions

At the beginning of each player's draw step, that player draws an additional card.
Whenever a player draws a card, Spiteful Visions deals 1 damage to that player.

Kaito, Cunning Infiltrator

Whenever a creature you control deals combat damage to a player, put a loyalty counter on Kaito.
+1: Up to one target creature you control can't be blocked this turn. Draw a card, then discard a card.
−2: Create a 2/1 blue Ninja creature token.
−9: You get an emblem with "Whenever a player casts a spell, you create a 2/1 blue Ninja creature token."

Mage Hunter

Whenever an opponent casts or copies an instant or sorcery spell, they lose 1 life.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Bloodroot Apothecary

Toxic 2 (Players dealt combat damage by this creature also get two poison counters. A player with ten or more poison counters loses the game.)
When Bloodroot Apothecary enters, you and target opponent each create a Treasure token.
Whenever an opponent sacrifices a noncreature token, that player gets two poison counters.

Taurean Mauler

Changeling (This card is every creature type.)
Whenever an opponent casts a spell, you may put a +1/+1 counter on Taurean Mauler.

Dirtcowl Wurm

Whenever an opponent plays a land, put a +1/+1 counter on Dirtcowl Wurm.

Chancellor of the Annex

You may reveal this card from your opening hand. If you do, when each opponent casts their first spell of the game, counter that spell unless that player pays {1}.
Flying
Whenever an opponent casts a spell, counter it unless that player pays {1}.

Revel in Silence

Your opponents can't cast spells or activate planeswalkers' loyalty abilities this turn.
Exile Revel in Silence.

Flamescroll Celebrant

Whenever an opponent activates an ability that isn't a mana ability, Flamescroll Celebrant deals 1 damage to that player.
{1}{R}: Flamescroll Celebrant gets +2/+0 until end of turn.

Flamescroll Celebrant // Revel in Silence

Sauron, the Dark Lord

Ward—Sacrifice a legendary artifact or legendary creature.
Whenever an opponent casts a spell, amass Orcs 1.
Whenever an Army you control deals combat damage to a player, the Ring tempts you.
Whenever the Ring tempts you, you may discard your hand. If you do, draw four cards.

Talion, the Kindly Lord

Flying
As Talion, the Kindly Lord enters, choose a number between 1 and 10.
Whenever an opponent casts a spell with mana value, power, or toughness equal to the chosen number, that player loses 2 life and you draw a card.

Knowledge Pool

Imprint — When Knowledge Pool enters, each player exiles the top three cards of their library.
Whenever a player casts a spell from their hand, that player exiles it. If the player does, they may cast a spell from among other cards exiled with Knowledge Pool without paying its mana cost.

Pyrostatic Pillar

Whenever a player casts a spell with mana value 3 or less, Pyrostatic Pillar deals 2 damage to that player.

Burning Earth

Whenever a player taps a nonbasic land for mana, Burning Earth deals 1 damage to that player.

Cindervines

Whenever an opponent casts a noncreature spell, Cindervines deals 1 damage to that player.
{1}, Sacrifice Cindervines: Destroy target artifact or enchantment. Cindervines deals 2 damage to that permanent's controller.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Cemetery Gatekeeper

First strike
When Cemetery Gatekeeper enters, exile a card from a graveyard.
Whenever a player plays a land or casts a spell, if it shares a card type with the exiled card, Cemetery Gatekeeper deals 2 damage to that player.

Forgotten Ancient

Whenever a player casts a spell, you may put a +1/+1 counter on Forgotten Ancient.
At the beginning of your upkeep, you may move any number of +1/+1 counters from Forgotten Ancient onto other creatures.

Karazikar, the Eye Tyrant

Whenever you attack a player, tap target creature that player controls and goad it. (Until your next turn, that creature attacks each combat if able and attacks a player other than you if able.)
Whenever an opponent attacks another one of your opponents, you and the attacking player each draw a card and lose 1 life.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Thundering Mightmare

Soulbond (You may pair this creature with another unpaired creature when either enters. They remain paired for as long as you control both of them.)
As long as Thundering Mightmare is paired with another creature, each of those creatures has "Whenever an opponent casts a spell, put a +1/+1 counter on this creature."

Jin-Gitaxias, Progress Tyrant

Whenever you cast an artifact, instant, or sorcery spell, copy that spell. You may choose new targets for the copy. This ability triggers only once each turn. (A copy of a permanent spell becomes a token.)
Whenever an opponent casts an artifact, instant, or sorcery spell, counter that spell. This ability triggers only once each turn.

Vazi, Keen Negotiator

Haste
{T}: Target opponent creates X Treasure tokens, where X is the number of Treasure tokens you created this turn.
Whenever an opponent casts a spell or activates an ability, if mana from a Treasure was spent to cast it or activate it, put a +1/+1 counter on target creature, then draw a card.

Burning-Tree Shaman

Whenever a player activates an ability that isn't a mana ability, Burning-Tree Shaman deals 1 damage to that player.

Mana Breach

Whenever a player casts a spell, that player returns a land they control to its owner's hand.

Swindler's Scheme

Whenever an opponent casts a spell from their hand, you may reveal the top card of your library. If it shares a card type with that spell, counter that spell and that opponent may cast the revealed card without paying its mana cost.

Leela, Sevateem Warrior

Whenever an opponent draws a card except the first one they draw in each of their draw steps, put a +1/+1 counter on Leela, Sevateem Warrior.
Doctor's companion (You can have two commanders if the other is the Doctor.)

Ishai, Ojutai Dragonspeaker

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Ishai, Ojutai Dragonspeaker.
Partner (You can have two commanders if both have partner.)

Planar Chaos

At the beginning of your upkeep, flip a coin. If you lose the flip, sacrifice Planar Chaos.
Whenever a player casts a spell, that player flips a coin. If they lose the flip, counter that spell.

Oppression

Whenever a player casts a spell, that player discards a card.

Lavinia, Azorius Renegade

Each opponent can't cast noncreature spells with mana value greater than the number of lands that player controls.
Whenever an opponent casts a spell, if no mana was spent to cast it, counter that spell.

Infesting Radroach

Flying
Infesting Radroach can't block.
Whenever Infesting Radroach deals combat damage to a player, they get that many rad counters.
Whenever an opponent mills a nonland card, if Infesting Radroach is in your graveyard, you may return it to your hand.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Mayhem Devil

Whenever a player sacrifices a permanent, Mayhem Devil deals 1 damage to any target.

Hunting Grounds

Threshold — As long as seven or more cards are in your graveyard, Hunting Grounds has "Whenever an opponent casts a spell, you may put a creature card from your hand onto the battlefield."

Powerbalance

Whenever an opponent casts a spell, you may reveal the top card of your library. If you do, you may cast that card without paying its mana cost if the two spells have the same mana value.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Niv-Mizzet, Parun

This spell can't be countered.
Flying
Whenever you draw a card, Niv-Mizzet, Parun deals 1 damage to any target.
Whenever a player casts an instant or sorcery spell, you draw a card.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Spelltithe Enforcer

Whenever an opponent casts a spell, that player sacrifices a permanent of their choice unless they pay {1}.

Blood Tyrant

Flying, trample
At the beginning of your upkeep, each player loses 1 life. Put a +1/+1 counter on Blood Tyrant for each 1 life lost this way.
Whenever a player loses the game, put five +1/+1 counters on Blood Tyrant.

Nezahal, Primal Tide

This spell can't be countered.
You have no maximum hand size.
Whenever an opponent casts a noncreature spell, draw a card.
Discard three cards: Exile Nezahal, Primal Tide. Return it to the battlefield tapped under its owner's control at the beginning of the next end step.

Combat Calligrapher

Flying
Inklings can't attack you or planeswalkers you control.
Whenever a player attacks one of your opponents, that attacking player creates a tapped 2/1 white and black Inkling creature token with flying that's attacking that opponent.

Jace, Unraveler of Secrets

+1: Scry 1, then draw a card.
−2: Return target creature to its owner's hand.
−8: You get an emblem with "Whenever an opponent casts their first spell each turn, counter that spell."

Hive Mind

Whenever a player casts an instant or sorcery spell, each other player copies that spell. Each of those players may choose new targets for their copy.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Bold Plagiarist

Flash
Whenever an opponent puts one or more counters on a creature they control, they put the same number and kind of counters on Bold Plagiarist.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Legate Lanius, Caesar's Ace

Decimate — When Legate Lanius enters, each opponent sacrifices a tenth of the creatures they control of their choice, rounded up.
Whenever an opponent sacrifices a creature, put a +1/+1 counter on Legate Lanius.

Geometric Nexus

Whenever a player casts an instant or sorcery spell, put a number of charge counters on Geometric Nexus equal to that spell's mana value.
{6}, {T}, Remove all charge counters from Geometric Nexus: Create a 0/0 green and blue Fractal creature token. Put X +1/+1 counters on it, where X is the number of charge counters removed this way.

Mind's Dilation

Whenever an opponent casts their first spell each turn, that player exiles the top card of their library. If it's a nonland card, you may cast it without paying its mana cost.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Vexing Bauble

Whenever a player casts a spell, if no mana was spent to cast it, counter that spell.
{1}, {T}, Sacrifice Vexing Bauble: Draw a card.

Void Mirror

Whenever a player casts a spell, if no colored mana was spent to cast it, counter that spell.

Magebane Lizard

Whenever a player casts a noncreature spell, Magebane Lizard deals damage to that player equal to the number of noncreature spells they've cast this turn.

Rod of Absorption

Whenever a player casts an instant or sorcery spell, exile it instead of putting it into a graveyard as it resolves.
{X}, {T}, Sacrifice Rod of Absorption: You may cast any number of spells from among cards exiled with Rod of Absorption with total mana value X or less without paying their mana costs.

River Song's Diary

Imprint — Whenever a player casts an instant or sorcery spell from their hand, exile it instead of putting it into a graveyard as it resolves.
At the beginning of your upkeep, if there are four or more cards exiled with River Song's Diary, choose one of them at random. You may cast it without paying its mana cost.

Dragonlair Spider

Reach
Whenever an opponent casts a spell, create a 1/1 green Insect creature token.

Carmen, Cruel Skymarcher

Flying
Whenever a player sacrifices a permanent, put a +1/+1 counter on Carmen, Cruel Skymarcher and you gain 1 life.
Whenever Carmen attacks, return up to one target permanent card with mana value less than or equal to Carmen's power from your graveyard to the battlefield.

Rocco, Street Chef

At the beginning of your end step, each player exiles the top card of their library. Until your next end step, each player may play the card they exiled this way.
Whenever a player plays a land from exile or casts a spell from exile, you put a +1/+1 counter on target creature and create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Runic Armasaur

Whenever an opponent activates an ability of a creature or land that isn't a mana ability, you may draw a card.

Heartwood Storyteller

Whenever a player casts a noncreature spell, each of that player's opponents may draw a card.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Soul Barrier

Whenever an opponent casts a creature spell, Soul Barrier deals 2 damage to that player unless they pay {2}.