Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Swamp

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Dark Ritual

Bloodthirsty Conqueror

Flying, deathtouch
Whenever an opponent loses life, you gain that much life. (Damage causes loss of life.)

Sol Ring

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Plains

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Elenda, Saint of Dusk

Lifelink, hexproof from instants
As long as your life total is greater than your starting life total, Elenda gets +1/+1 and has menace. Elenda gets an additional +5/+5 as long as your life total is at least 10 greater than your starting life total.

Caduceus, Staff of Hermes

Equipped creature has lifelink.
As long as you have 30 or more life, equipped creature gets +5/+5 and has indestructible and "Prevent all damage that would be dealt to this creature."
Equip {W}{W}

Mortify

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Angel of Destiny

Flying, double strike
Whenever a creature you control deals combat damage to a player, you and that player each gain that much life.
At the beginning of your end step, if you have at least 15 life more than your starting life total, each player Angel of Destiny attacked this turn loses the game.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Lae'zel, Vlaakith's Champion

If you would put one or more counters on a creature or planeswalker you control or on yourself, put that many plus one of each of those kinds of counters on that permanent or player instead.
Choose a Background (You can have a Background as a second commander.)

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Damnation

Destroy all creatures. They can't be regenerated.

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Soul Warden

Whenever another creature enters, you gain 1 life.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Sorin, Ravenous Neonate

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
+2: Create a Food token.
−1: Sorin, Ravenous Neonate deals damage equal to the amount of life you gained this turn to any target.
−6: Gain control of target creature. It becomes a Vampire in addition to its other types. Put a lifelink counter on it if you control a white permanent other than that creature or Sorin.

Sorin of House Markov

Lifelink
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
At the beginning of each of your postcombat main phases, if you gained 3 or more life this turn, exile Sorin of House Markov, then return him to the battlefield transformed under his owner's control.

Sorin of House Markov // Sorin, Ravenous Neonate

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Lae'zel's Acrobatics

Exile all nontoken creatures you control, then roll a d20.
1—9 | Return those cards to the battlefield under their owner's control at the beginning of the next end step.
10—20 | Return those cards to the battlefield under their owner's control, then exile them again. Return those cards to the battlefield under their owner's control at the beginning of the next end step.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Gift of Fangs

Enchant creature
Enchanted creature gets +2/+2 as long as it's a Vampire. Otherwise, it gets -2/-2.

Shadowheart, Dark Justiciar

{1}{B}, {T}, Sacrifice another creature: Draw X cards, where X is that creature's power.
Choose a Background (You can have a Background as a second commander.)

Astarion's Thirst

Exile target creature. Put X +1/+1 counters on a commander creature you control, where X is the power of the creature exiled this way.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Nykthos Paragon

Whenever you gain life, you may put that many +1/+1 counters on each creature you control. Do this only once each turn.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Minthara, Merciless Soul

Minthara has ward {X}, where X is the number of experience counters you have.
At the beginning of your end step, if a permanent you controlled left the battlefield this turn, you get an experience counter.
Creatures you control get +1/+0 for each experience counter you have.

Baldur's Gate

{T}: Add {C}.
{2}, {T}: Add X mana of any one color, where X is the number of other Gates you control.

Command Tower

Grievous Wound

Enchant player
Enchanted player can't gain life.
Whenever enchanted player is dealt damage, they lose half their life, rounded up.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Orzhov Signet

Quietus Spike

Equipped creature has deathtouch.
Whenever equipped creature deals combat damage to a player, that player loses half their life, rounded up.
Equip {3}

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Life Insurance

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever a nontoken creature dies, you lose 1 life and create a Treasure token.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)