Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Caress of Phyrexia

Target player draws three cards, loses 3 life, and gets three poison counters.

Mikokoro, Center of the Sea

{T}: Add {C}.
{2}, {T}: Each player draws a card.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Gnat Miser

Each opponent's maximum hand size is reduced by one.

Murder

Clockwork Fox

When Clockwork Fox leaves the battlefield, you draw two cards and each opponent draws a card.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Corrupted Conviction

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Black Sun's Twilight

Up to one target creature gets -X/-X until end of turn. If X is 5 or more, return a creature card with mana value X or less from your graveyard to the battlefield tapped.

Necrogoyf

Necrogoyf's power is equal to the number of creature cards in all graveyards.
At the beginning of each player's upkeep, that player discards a card.
Madness {1}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Rankle's Prank

Choose one or more —
• Each player discards two cards.
• Each player loses 4 life.
• Each player sacrifices two creatures of their choice.

Fell Specter

Flying
When Fell Specter enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Bonders' Enclave

{T}: Add {C}.
{3}, {T}: Draw a card. Activate only if you control a creature with power 4 or greater.

The Haunt of Hightower

Flying, lifelink
Whenever The Haunt of Hightower attacks, defending player discards a card.
Whenever a card is put into an opponent's graveyard from anywhere, put a +1/+1 counter on The Haunt of Hightower.

Geier Reach Sanitarium

{T}: Add {C}.
{2}, {T}: Each player draws a card, then discards a card.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Liliana's Specter

Flying
When Liliana's Specter enters, each opponent discards a card.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Magus of the Coffers

{2}, {T}: Add {B} for each Swamp you control.

Infernal Grasp

Destroy target creature. You lose 2 life.

Runed Servitor

When Runed Servitor dies, each player draws a card.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Scrawling Crawler

At the beginning of your upkeep, each player draws a card.
Whenever an opponent draws a card, that player loses 1 life.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Harrowing Journey

Target player draws three cards and loses 3 life.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Bloodthirsty Conqueror

Flying, deathtouch
Whenever an opponent loses life, you gain that much life. (Damage causes loss of life.)

Elder Brain

Menace
Whenever Elder Brain attacks a player, exile all cards from that player's hand, then they draw that many cards. You may play lands and cast spells from among the exiled cards for as long as they remain exiled. If you cast a spell this way, you may spend mana as though it were mana of any color to cast it.

Painful Lesson

Target player draws two cards and loses 2 life.

Manalith

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Harvester of Souls

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Whenever another nontoken creature dies, you may draw a card.

Blood Pact

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

That Which Was Taken

{4}, {T}: Put a divinity counter on target permanent other than That Which Was Taken.
Each permanent with a divinity counter on it has indestructible.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Mana Geode

When Mana Geode enters, scry 1.
{T}: Add one mana of any color.

The Raven Man

At the beginning of each end step, if a player discarded a card this turn, create a 1/1 black Bird creature token with flying and "This creature can't block."
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Sign in Blood

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Sol Ring

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Temple Bell

Otherworld Atlas

{T}: Put a charge counter on Otherworld Atlas.
{T}: Each player draws a card for each charge counter on Otherworld Atlas.

Shizo, Death's Storehouse

{T}: Add {B}.
{B}, {T}: Target legendary creature gains fear until end of turn. (It can't be blocked except by artifact creatures and/or black creatures.)

Price of Knowledge

Players have no maximum hand size.
At the beginning of each opponent's upkeep, Price of Knowledge deals damage to that player equal to the number of cards in that player's hand.

Starscape Cleric

Offspring {2}{B} (You may pay an additional {2}{B} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Flying
This creature can't block.
Whenever you gain life, each opponent loses 1 life.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice this artifact: Draw two cards.

Hypnotic Specter

Flying
Whenever Hypnotic Specter deals damage to an opponent, that player discards a card at random.

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Damnable Pact

Target player draws X cards and loses X life.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Mikaeus, the Unhallowed

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a Human deals damage to you, destroy it.
Other non-Human creatures you control get +1/+1 and have undying. (When a creature with undying dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Urgoros, the Empty One

Flying
Whenever Urgoros, the Empty One deals combat damage to a player, that player discards a card at random. If the player can't, you draw a card.

Howling Golem

Whenever Howling Golem attacks or blocks, each player draws a card.

Palladium Myr

Liliana, Defiant Necromancer

+2: Each player discards a card.
−X: Return target nonlegendary creature card with mana value X from your graveyard to the battlefield.
−8: You get an emblem with "Whenever a creature dies, return it to the battlefield under your control at the beginning of the next end step."

Liliana, Heretical Healer

Lifelink
Whenever another nontoken creature you control dies, exile Liliana, Heretical Healer, then return her to the battlefield transformed under her owner's control. If you do, create a 2/2 black Zombie creature token.